- Each point of Toxicity increases damage dealt by swords and Sign Intensity by 0.75% (to a maximum of 75%)
- The description can be misleading as the 75% limit applies only to the base toxicity pool, thus using effects that increase the pool capacity will also increase the limit.
- The mutation works extraordinarily well with Acquired Tolerance, which not only increases the toxicity pool but also, being a skill from the alchemy tree, can be inserted into the additional slots. Thus even if one does not normally use alchemy skills in their build it can still be added for maximum benefit.
- At maximum Acquired Tolerance can increase the toxicity pool to 267 which brings the limit up to 200.25%.
- The pool can be increased further using Metabolic Control and/or Manticore School Gear. When all boosts are put together it increases the toxicity pool capacity up to 327 (332 in New Game +) increasing the limit to 245.25% (249% NG+)
- Another skill worth using along with the mutation is Heightened Tolerance which will eliminate the damage caused by high toxicity.
- Since the effect increases both damage and sign intensity it works best with hybrid builds relying on both combat and signs.
- Like most effects that boost stats the skill will only take base damage into consideration and ignore all other boosts. Even so the damage boost will be enormous.
- Having such high sign intensity will cause signs to have devastating effects. For example Igni will gain a 100% chance to burn it's victims.
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