Greater blue mutagen is an alchemy ingredient and is used to augment abilities and are more effective than their lesser and regular counterparts. When placed in the diamond-shaped slot in the character panel, they give +10% to sign intensity, which increases by 10 up to a max of +40% if all 3 skills attached to it are blue.

Blood and Wine expansion

With Blood and Wine, the player can now craft these with other ingredients that don't include blue mutagens.

Crafting Requirements Tw2 icon crafting
Crafting Requirements Tw2 icon crafting


  • In an undocumented change for Patch 1.08, all mutagen icons were changed. However, there was still a bug for those on Steam and Origin that didn't reflect this and was later fixed in Patch 1.22. Despite this, some may still see the original icons instead, even with a fully patched game.
Community content is available under CC-BY-SA unless otherwise noted.