Orianna appeared to be very wealthy and a philanthropist, owning an orphanage and an estate, where at the latter she hosted lavish parties for artists, one of which Geralt and Anna Henrietta attended in disguise. She also paid a good deal of money to acquire the Heart of Toussaint, an heirloom that had been passed down through Toussaint's royal family but was lost when the last one to inherit it, Princess Sylvia Anna, was exiled from the kingdom. Orianna also appeared to be acquainted with Dettlaff and Regis, where she stated the latter as her friend from the past.
However, her generosity with owning an orphanage turned out to have more sinister motives. Like many vampires, Orianna had a craving for blood but she preferred children's blood and periodically fed off the children there to satisfy her craving.
Encountering Geralt second time and death
Seemingly a few years past, as Geralt promised when leaving Orianna's orphanage, he came back for her. Geralt approached and remarked on remembering the tune he last heard from the orphanage Orianna hummed. He noted that the locals paid him for her, she remarked that in times past witchers would never take such a contract. She then threw off her clothes transforming into her invisible form and unnaturally quickly disappeared in the nearby barn.
Geralt drank a bottle of Black Blood. Entering the barn, he threw a Moon Dust bomb which partially revealed Orianna in her invisible form. A duel ensued which resulted in Orianna gaining the upper hand, biting Geralt at his neck. Although she didn't realize the Black Blood potion effects until it was too late, giving Geralt the opportunity to win and she quickly lost the fight. Losing her left arm, she tried to escape but a shot from Geralt's crossbow at her back sealed the deal.
Geralt followed up by preparing his hook for a trophy but collapsed alongside her from his injuries, seeing her last tear and agony. When Geralt woke up, he left her disintegrating body without taking the trophy and rode on his faithful Roach away in a hurry towards Beauclair.
- During the soiree organized by the Mandragora, Geralt met Orianna, a valued patroness to many local artists. There was something about this woman that made most who met her feel somehow ill at ease. She could not break the witcher's iron-hard self-composure, of course, but she did give him the impression she was no normal aristocrat – and his impressions were usually spot-on.
- Regis' charismatic friend was revealed to be a fellow vampire, though nowhere near as civilized and humanitarian as he. She owned an orphanage outside the city which, as the witcher discovered to his horror, she used as a sort of blood cellar, visiting it whenever the urge struck her to drink some blood straight from an orphan's neck. Geralt swore that if they ever met again...
- She was played by Zsuzsanna Rácz in the trailer and voiced by Laura Doddington in both the trailer and the game. Rácz stated on her personal Twitter that it is "one of her best works".
- Originally, fans were divided over Orianna's exact race, with the developers neither confirming nor denying it. The narrative designer, Mateusz Tomaszkiewicz, later confirmed it was better to classify her as a bruxa.