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In The Witcher 2: Assassins of Kings, mutagens are powerful mutation-triggering agents and (with patch 1.3 installed) alchemy ingredients. They allow you to raise your abilities even further. Mutagens can be acquired in two ways: you can loot them from defeated enemy corpses or you can create them as random by-products of alchemy. To undergo mutation, enter meditation and then select the "Character" option and find a skill with a mutagen slot. Mutations cannot be reversed; as such, it is strongly recommended that you never use lesser or basic mutagens, only greater ones. It is also recommended to have the Impregnation talent from the alchemy tree at level 2 before using any mutagens, because that skill does not affect mutagens which have already been applied.

Impregnation exploit with The Operator[]

As of patch 1.1: For those not focusing on the alchemy tree, it is possible to enjoy the Impregnation benefit without ultimately keeping the skill. One may put enough points in the alchemy tree to get Impregnation to level 2, then invest in other trees (not the alchemy tree) as much as possible to get Mutagen skills. In Chapter 3, before you meet The Operator during the quest From a Bygone Era, make sure you have all the mutagens applied already. Then accept his offer to reallocate your talents using the mysterious artifact. In the immediate talent distribution screen, re-pick all the skills in trees except the alchemy tree. The improved mutagens will remain even though you no longer have Impregnation.

As of patch 2.1: The effects of used mutagens remain even without selecting the skill. After accepting the offer to re-allocate skill points, you will notice that attributes are boosted even without selecting any skill. It is possible to utilize all 13 slots this way. However, it resets back to normal once you save and reload.

Finding Greater Mutagens[]

If you have seen a frustratingly low number of greater mutagen drops from slain enemies, you might try allocating some points into Side Effect. With 2 points in this alchemy tree skill there will be a 10% chance of mutagens being created as a byproduct of alchemy. Often multiple mutagens are created simultaneously from the same alchemical concoction. There are some alchemical concoctions that require only a few common ingredients, such as the Grapeshot bomb. You can create them one at a time, and they occasionally produce several greater mutagens in the same go. If you do not want to spend the points in that skill, you could do it early in the game to harvest mutagens, then use the impregnation exploit described above.

List of Mutagens[]

Mutagens usually take one of three forms: lesser, basic and greater. Each of these forms raises Geralt's statistics by different amounts.

Icon Potency Name Effect (Tw2 skill impregnation with Impregnation 1 / with Impregnation 2) Tw2 icon alchemy
Lesser enhancement mutagen
Lesser Enhancement Adrenaline generation on hitting foe +1% (+3% / +6%) Vitriol tw2
Enhancement mutagen
Basic Enhancement Adrenaline generation on hitting foe +3% (+5% / +8%) Vitriol tw2
Greater enhancement mutagen
Greater Enhancement Adrenaline generation on hitting foe +5% (+7% / +10%) Vitriol tw2
Lesser critical effects mutagen
Lesser Critical effects Chance of all critical effects +1% (+2% / +4%) Rebis tw2
Critical effects mutagen
Basic Critical effects Chance of all critical effects +2% (+3% / +5%) Rebis tw2
Greater criticals effect mutagen
Greater Critical effects Chance of all critical effects +3% (+4% / +6%) Rebis tw2
Madness mutagen
Basic Madness Armor +2 (+3 / +4), Vitality +5 (+10 / +15), Damage bonus on Signs +1 (+2 / +3) Caelum tw2
Lesser power mutagen
Lesser Power Sword damage +1 (+2 / +3 – 4) Quebrith tw2
Power mutagen
Basic Power Sword damage +1 – 2 (+2 – 3 / +3 – 5) Quebrith tw2
Greater power mutagen
Greater Power Sword damage +1 – 3 (+2 – 4 / +3 – 6) Quebrith tw2
Lesser strength mutagen
Lesser Strength Armor +1 (+2 / +3) Vermilion tw2
Strength mutagen
Basic Strength Armor +2 (+3 / +4) Vermilion tw2
Greater strength mutagen
Greater Strength Armor +2 (+3 / +4), Vitality regeneration +1 Vermilion tw2
Lesser vitality mutagen
Lesser Vitality Vitality +2 (+7 / +12) Hydragenum tw2
Vitality mutagen
Basic Vitality Vitality +5 (+10 / +15) Hydragenum tw2
Greater vitality mutagen
Greater Vitality Vitality +10 (+15 / +20) Hydragenum tw2
Concentration mutagen
Basic Concentration Damage bonus on Signs +1 (+2 / +3) Caelum tw2
Lesser range mutagen
Lesser Range Sign range Aard and Igni +2% (+4% / +6%) Aether tw2
Range mutagen
Basic Range Sign range Aard and Igni +5% (+7% / +9%) Aether tw2